Molecular mechanisms of ethanol biotransformation: enzymes of oxidative and nonoxidative metabolic pathways in human.
Identifieur interne : 000019 ( Main/Exploration ); précédent : 000018; suivant : 000020Molecular mechanisms of ethanol biotransformation: enzymes of oxidative and nonoxidative metabolic pathways in human.
Auteurs : Gra Yna Kubiak-Tomaszewska [Pologne] ; Piotr Tomaszewski [Pologne] ; Jan Pachecka [Pologne] ; Marta Struga [Pologne] ; Wioletta Olejarz [Pologne] ; Magdalena Mielczarek-Puta [Pologne] ; Gra Yna Nowicka [Pologne]Source :
- Xenobiotica; the fate of foreign compounds in biological systems [ 1366-5928 ] ; 2020.
Descripteurs français
- KwdFr :
- MESH :
- métabolisme : Catalase, Microsomes du foie, Éthanol.
- physiologie : Biotransformation.
- Acétaldéhyde, Humains, Oxydoréduction, Taux de clairance métabolique, Voies et réseaux métaboliques.
English descriptors
- KwdEn :
- MESH :
- chemical , metabolism : Catalase, Ethanol.
- chemical : Acetaldehyde.
- metabolism : Microsomes, Liver.
- physiology : Biotransformation.
- Humans, Metabolic Clearance Rate, Metabolic Networks and Pathways, Oxidation-Reduction.
Abstract
Ethanol, as a small-molecule organic compound exhibiting both hydrophilic and lipophilic properties, quickly pass through the biological barriers. Over 95% of absorbed ethanol undergoes biotransformation, the remaining amount is excreted unchanged, mainly with urine and exhaled air.The main route of ethyl alcohol metabolism is its oxidation to acetaldehyde, which is converted into acetic acid with the participation of cytosolic NAD+ - dependent alcohol (ADH) and aldehyde (ALDH) dehydrogenases. Oxidative biotransformation pathways of ethanol also include reactions catalyzed by the microsomal ethanol oxidizing system (MEOS), peroxisomal catalase and aldehyde (AOX) and xanthine (XOR) oxidases. The resulting acetic acid can be activated to acetyl-CoA by the acetyl-CoA synthetase (ACS).It is also possible, to a much smaller extent, non-oxidative routes of ethanol biotransformation including its esterification with fatty acids by ethyl fatty acid synthase (FAEES), re-esterification of phospholipids, especially phosphatidylcholines, with phospholipase D (PLD), coupling with sulfuric acid by alcohol sulfotransferase (SULT) and with glucuronic acid using UDP-glucuronyl transferase (UGT, syn. UDPGT).The intestinal microbiome plays a significant role in the ethanol biotransformation and in the initiation and progression of liver diseases stimulated by ethanol and its metabolite - acetaldehyde, or by lipopolysaccharide and ROS.
DOI: 10.1080/00498254.2020.1761571
PubMed: 32338108
Affiliations:
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human.</title><author><name sortKey="Kubiak Tomaszewska, Gra Yna" sort="Kubiak Tomaszewska, Gra Yna" uniqKey="Kubiak Tomaszewska G" first="Gra Yna" last="Kubiak-Tomaszewska">Gra Yna Kubiak-Tomaszewska</name><affiliation wicri:level="1"><nlm:affiliation>Department of Biochemistry and Clinical Chemistry, Faculty of Pharmacy, Medical University of Warsaw, Warsaw, Poland.</nlm:affiliation><country xml:lang="fr">Pologne</country><wicri:regionArea>Department of Biochemistry and Clinical Chemistry, Faculty of Pharmacy, Medical University of Warsaw, Warsaw</wicri:regionArea><wicri:noRegion>Warsaw</wicri:noRegion></affiliation></author><author><name sortKey="Tomaszewski, Piotr" sort="Tomaszewski, Piotr" uniqKey="Tomaszewski P" first="Piotr" last="Tomaszewski">Piotr Tomaszewski</name><affiliation wicri:level="1"><nlm:affiliation>Department of Biochemistry and Clinical Chemistry, Faculty of Pharmacy, Medical University of Warsaw, Warsaw, Poland.</nlm:affiliation><country xml:lang="fr">Pologne</country><wicri:regionArea>Department of Biochemistry and Clinical Chemistry, Faculty of Pharmacy, Medical University of Warsaw, Warsaw</wicri:regionArea><wicri:noRegion>Warsaw</wicri:noRegion></affiliation></author><author><name sortKey="Pachecka, Jan" sort="Pachecka, Jan" uniqKey="Pachecka J" first="Jan" last="Pachecka">Jan Pachecka</name><affiliation wicri:level="1"><nlm:affiliation>Department of Biochemistry and Clinical Chemistry, Faculty of Pharmacy, Medical University of Warsaw, Warsaw, Poland.</nlm:affiliation><country xml:lang="fr">Pologne</country><wicri:regionArea>Department of Biochemistry and Clinical Chemistry, Faculty of Pharmacy, Medical University of Warsaw, Warsaw</wicri:regionArea><wicri:noRegion>Warsaw</wicri:noRegion></affiliation></author><author><name sortKey="Struga, Marta" sort="Struga, Marta" uniqKey="Struga M" first="Marta" last="Struga">Marta Struga</name><affiliation wicri:level="1"><nlm:affiliation>Department of Biochemistry, Faculty of Medicine, Medical University of Warsaw, Warsaw, Poland.</nlm:affiliation><country xml:lang="fr">Pologne</country><wicri:regionArea>Department of Biochemistry, Faculty of Medicine, Medical University of Warsaw, Warsaw</wicri:regionArea><wicri:noRegion>Warsaw</wicri:noRegion></affiliation></author><author><name sortKey="Olejarz, Wioletta" sort="Olejarz, Wioletta" uniqKey="Olejarz W" first="Wioletta" last="Olejarz">Wioletta Olejarz</name><affiliation wicri:level="1"><nlm:affiliation>Department of Biochemistry and Clinical Chemistry, Faculty of Pharmacy, Medical University of Warsaw, Warsaw, Poland.</nlm:affiliation><country xml:lang="fr">Pologne</country><wicri:regionArea>Department of Biochemistry and Clinical Chemistry, Faculty of Pharmacy, Medical University of Warsaw, Warsaw</wicri:regionArea><wicri:noRegion>Warsaw</wicri:noRegion></affiliation></author><author><name sortKey="Mielczarek Puta, Magdalena" sort="Mielczarek Puta, Magdalena" uniqKey="Mielczarek Puta M" first="Magdalena" last="Mielczarek-Puta">Magdalena Mielczarek-Puta</name><affiliation wicri:level="1"><nlm:affiliation>Department of Biochemistry, Faculty of Medicine, Medical University of Warsaw, Warsaw, Poland.</nlm:affiliation><country xml:lang="fr">Pologne</country><wicri:regionArea>Department of Biochemistry, Faculty of Medicine, Medical University of Warsaw, Warsaw</wicri:regionArea><wicri:noRegion>Warsaw</wicri:noRegion></affiliation></author><author><name sortKey="Nowicka, Gra Yna" sort="Nowicka, Gra Yna" uniqKey="Nowicka G" first="Gra Yna" last="Nowicka">Gra Yna Nowicka</name><affiliation wicri:level="1"><nlm:affiliation>Department of Biochemistry and Clinical Chemistry, Faculty of Pharmacy, Medical University of Warsaw, Warsaw, Poland.</nlm:affiliation><country xml:lang="fr">Pologne</country><wicri:regionArea>Department of Biochemistry and Clinical Chemistry, Faculty of Pharmacy, Medical University of Warsaw, Warsaw</wicri:regionArea><wicri:noRegion>Warsaw</wicri:noRegion></affiliation></author></analytic><series><title level="j">Xenobiotica; the fate of foreign compounds in biological systems</title><idno type="eISSN">1366-5928</idno><imprint><date when="2020" type="published">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Acetaldehyde (MeSH)</term><term>Biotransformation (physiology)</term><term>Catalase (metabolism)</term><term>Ethanol (metabolism)</term><term>Humans (MeSH)</term><term>Metabolic Clearance Rate (MeSH)</term><term>Metabolic Networks and Pathways (MeSH)</term><term>Microsomes, Liver (metabolism)</term><term>Oxidation-Reduction (MeSH)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Acétaldéhyde (MeSH)</term><term>Biotransformation (physiologie)</term><term>Catalase (métabolisme)</term><term>Humains (MeSH)</term><term>Microsomes du foie (métabolisme)</term><term>Oxydoréduction (MeSH)</term><term>Taux de clairance métabolique (MeSH)</term><term>Voies et réseaux métaboliques (MeSH)</term><term>Éthanol (métabolisme)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Catalase</term><term>Ethanol</term></keywords><keywords scheme="MESH" type="chemical" xml:lang="en"><term>Acetaldehyde</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Microsomes, Liver</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Catalase</term><term>Microsomes du foie</term><term>Éthanol</term></keywords><keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Biotransformation</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Biotransformation</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Humans</term><term>Metabolic Clearance Rate</term><term>Metabolic Networks and Pathways</term><term>Oxidation-Reduction</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Acétaldéhyde</term><term>Humains</term><term>Oxydoréduction</term><term>Taux de clairance métabolique</term><term>Voies et réseaux métaboliques</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Ethanol, as a small-molecule organic compound exhibiting both hydrophilic and lipophilic properties, quickly pass through the biological barriers. Over 95% of absorbed ethanol undergoes biotransformation, the remaining amount is excreted unchanged, mainly with urine and exhaled air.The main route of ethyl alcohol metabolism is its oxidation to acetaldehyde, which is converted into acetic acid with the participation of cytosolic NAD<sup>+</sup> - dependent alcohol (ADH) and aldehyde (ALDH) dehydrogenases. Oxidative biotransformation pathways of ethanol also include reactions catalyzed by the microsomal ethanol oxidizing system (MEOS), peroxisomal catalase and aldehyde (AOX) and xanthine (XOR) oxidases. The resulting acetic acid can be activated to acetyl-CoA by the acetyl-CoA synthetase (ACS).It is also possible, to a much smaller extent, non-oxidative routes of ethanol biotransformation including its esterification with fatty acids by ethyl fatty acid synthase (FAEES), re-esterification of phospholipids, especially phosphatidylcholines, with phospholipase D (PLD), coupling with sulfuric acid by alcohol sulfotransferase (SULT) and with glucuronic acid using UDP-glucuronyl transferase (UGT, syn. UDPGT).The intestinal microbiome plays a significant role in the ethanol biotransformation and in the initiation and progression of liver diseases stimulated by ethanol and its metabolite - acetaldehyde, or by lipopolysaccharide and ROS.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">32338108</PMID><DateCompleted><Year>2020</Year><Month>09</Month><Day>08</Day></DateCompleted><DateRevised><Year>2020</Year><Month>09</Month><Day>08</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1366-5928</ISSN><JournalIssue CitedMedium="Internet"><Volume>50</Volume><Issue>10</Issue><PubDate><Year>2020</Year><Month>Oct</Month></PubDate></JournalIssue><Title>Xenobiotica; the fate of foreign compounds in biological systems</Title><ISOAbbreviation>Xenobiotica</ISOAbbreviation></Journal><ArticleTitle>Molecular mechanisms of ethanol biotransformation: enzymes of oxidative and nonoxidative metabolic pathways in human.</ArticleTitle><Pagination><MedlinePgn>1180-1201</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1080/00498254.2020.1761571</ELocationID><Abstract><AbstractText>Ethanol, as a small-molecule organic compound exhibiting both hydrophilic and lipophilic properties, quickly pass through the biological barriers. Over 95% of absorbed ethanol undergoes biotransformation, the remaining amount is excreted unchanged, mainly with urine and exhaled air.The main route of ethyl alcohol metabolism is its oxidation to acetaldehyde, which is converted into acetic acid with the participation of cytosolic NAD<sup>+</sup> - dependent alcohol (ADH) and aldehyde (ALDH) dehydrogenases. Oxidative biotransformation pathways of ethanol also include reactions catalyzed by the microsomal ethanol oxidizing system (MEOS), peroxisomal catalase and aldehyde (AOX) and xanthine (XOR) oxidases. The resulting acetic acid can be activated to acetyl-CoA by the acetyl-CoA synthetase (ACS).It is also possible, to a much smaller extent, non-oxidative routes of ethanol biotransformation including its esterification with fatty acids by ethyl fatty acid synthase (FAEES), re-esterification of phospholipids, especially phosphatidylcholines, with phospholipase D (PLD), coupling with sulfuric acid by alcohol sulfotransferase (SULT) and with glucuronic acid using UDP-glucuronyl transferase (UGT, syn. UDPGT).The intestinal microbiome plays a significant role in the ethanol biotransformation and in the initiation and progression of liver diseases stimulated by ethanol and its metabolite - acetaldehyde, or by lipopolysaccharide and ROS.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Kubiak-Tomaszewska</LastName><ForeName>Grażyna</ForeName><Initials>G</Initials><Identifier Source="ORCID">https://orcid.org/0000-0001-6502-7085</Identifier><AffiliationInfo><Affiliation>Department of Biochemistry and Clinical Chemistry, Faculty of Pharmacy, Medical University of Warsaw, Warsaw, Poland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Tomaszewski</LastName><ForeName>Piotr</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Department of Biochemistry and Clinical Chemistry, Faculty of Pharmacy, Medical University of Warsaw, Warsaw, Poland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Pachecka</LastName><ForeName>Jan</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Department of Biochemistry and Clinical Chemistry, Faculty of Pharmacy, Medical University of Warsaw, Warsaw, Poland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Struga</LastName><ForeName>Marta</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Department of Biochemistry, Faculty of Medicine, Medical University of Warsaw, Warsaw, Poland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Olejarz</LastName><ForeName>Wioletta</ForeName><Initials>W</Initials><AffiliationInfo><Affiliation>Department of Biochemistry and Clinical Chemistry, Faculty of Pharmacy, Medical University of Warsaw, Warsaw, Poland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Mielczarek-Puta</LastName><ForeName>Magdalena</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Department of Biochemistry, Faculty of Medicine, Medical University of Warsaw, Warsaw, Poland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Nowicka</LastName><ForeName>Grażyna</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>Department of Biochemistry and Clinical Chemistry, Faculty of Pharmacy, Medical University of Warsaw, Warsaw, Poland.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2020</Year><Month>05</Month><Day>13</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Xenobiotica</MedlineTA><NlmUniqueID>1306665</NlmUniqueID><ISSNLinking>0049-8254</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>3K9958V90M</RegistryNumber><NameOfSubstance UI="D000431">Ethanol</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 1.11.1.6</RegistryNumber><NameOfSubstance UI="D002374">Catalase</NameOfSubstance></Chemical><Chemical><RegistryNumber>GO1N1ZPR3B</RegistryNumber><NameOfSubstance UI="D000079">Acetaldehyde</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000079" MajorTopicYN="N">Acetaldehyde</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D001711" MajorTopicYN="N">Biotransformation</DescriptorName><QualifierName UI="Q000502" MajorTopicYN="Y">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D002374" MajorTopicYN="N">Catalase</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D000431" MajorTopicYN="N">Ethanol</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008657" MajorTopicYN="N">Metabolic Clearance Rate</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D053858" MajorTopicYN="N">Metabolic Networks and Pathways</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008862" MajorTopicYN="N">Microsomes, Liver</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D010084" MajorTopicYN="N">Oxidation-Reduction</DescriptorName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Ethanol metabolism</Keyword><Keyword MajorTopicYN="N">MEOS</Keyword><Keyword MajorTopicYN="N">alcohol and aldehyde dehydrogenases</Keyword><Keyword MajorTopicYN="N">catalase</Keyword><Keyword MajorTopicYN="N">ethanol esterification and conjugation</Keyword><Keyword MajorTopicYN="N">gut microbiome biotransformation of ethanol</Keyword><Keyword MajorTopicYN="N">non-oxidative ethanol biotransformation</Keyword><Keyword MajorTopicYN="N">oxidative ethanol biotransformation</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>2020</Year><Month>4</Month><Day>28</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2020</Year><Month>9</Month><Day>9</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2020</Year><Month>4</Month><Day>28</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">32338108</ArticleId><ArticleId IdType="doi">10.1080/00498254.2020.1761571</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Pologne</li></country></list><tree><country name="Pologne"><noRegion><name sortKey="Kubiak Tomaszewska, Gra Yna" sort="Kubiak Tomaszewska, Gra Yna" uniqKey="Kubiak Tomaszewska G" first="Gra Yna" last="Kubiak-Tomaszewska">Gra Yna Kubiak-Tomaszewska</name></noRegion><name sortKey="Mielczarek Puta, Magdalena" sort="Mielczarek Puta, Magdalena" uniqKey="Mielczarek Puta M" first="Magdalena" last="Mielczarek-Puta">Magdalena Mielczarek-Puta</name><name sortKey="Nowicka, Gra Yna" sort="Nowicka, Gra Yna" uniqKey="Nowicka G" first="Gra Yna" last="Nowicka">Gra Yna Nowicka</name><name sortKey="Olejarz, Wioletta" sort="Olejarz, Wioletta" uniqKey="Olejarz W" first="Wioletta" last="Olejarz">Wioletta Olejarz</name><name sortKey="Pachecka, Jan" sort="Pachecka, Jan" uniqKey="Pachecka J" first="Jan" last="Pachecka">Jan Pachecka</name><name sortKey="Struga, Marta" sort="Struga, Marta" uniqKey="Struga M" first="Marta" last="Struga">Marta Struga</name><name sortKey="Tomaszewski, Piotr" sort="Tomaszewski, Piotr" uniqKey="Tomaszewski P" first="Piotr" last="Tomaszewski">Piotr Tomaszewski</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix 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